Bromid peroksidaza
| Bromid peroksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.11.1.18 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Bromid peroksidaza (EC 1.11.1.18, bromoperoksidaza, haloperoksidaza (nespecifična), eozinofilna peroksidaza) je enzim sa sistematskim imenom bromid:vodonik-peroksid oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- RH + HBr + H2O2 RBr + 2H2O
Ove bromoperoksidaze crvenih i smeđih morskih algi (Rhodophyta i Phaeophyta) sadrže vanadat. One katalizuju brominaciju niza organskih molekula kao što su seskviterpeni, formirajući stabilne C-Br veze. Bromoperoksidaze takođe oksiduju jodide.
Reference
[уреди | уреди извор]- ^ De Boer, E., Tromp, M.G.M., Plat, H., Krenn, G.E. and Wever, R (1986). „Vanadium(v) as an essential element for haloperoxidase activity in marine brown-algae - purification and characterization of a vanadium(V)-containing bromoperoxidase from Laminaria saccharina”. Biochim. Biophys. Acta. 872: 104—115.
- ^ Tromp, M.G., Olafsson, G., Krenn, B.E. and Wever, R. (1990). „Some structural aspects of vanadium bromoperoxidase from Ascophyllum nodosum”. Biochim. Biophys. Acta. 1040: 192—198. PMID 2400770.
- ^ Isupov, M.N., Dalby, A.R., Brindley, A.A., Izumi, Y., Tanabe, T., Murshudov, G.N. and Littlechild, J.A. (2000). „Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis”. J. Mol. Biol. 299: 1035—1049. PMID 10843856.
- ^ Carter-Franklin, J.N. & Butler, A. (2004). „Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products”. J. Am. Chem. Soc. 126: 15060—15066. PMID 15548002.
- ^ Ohshiro, T., Littlechild, J., Garcia-Rodriguez, E., Isupov, M.N., Iida, Y., Kobayashi, T. and Izumi, Y. (2004). „Modification of halogen specificity of a vanadium-dependent bromoperoxidase”. Protein Sci. 13: 1566—1571. PMID 15133166.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Bromide+peroxidase на US National Library of Medicine Medical Subject Headings (MeSH)
